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The SURMOUNT-1 trial established tirzepatide efficacy with remarkable clarity

Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease

For more information about how BC Guidelines are developed, refer to the GPAC Handbook available at BCGuidelines.ca: GPAC Handbook

Its worth noting that AOD-9604 was very well tolerated in trials, with no major safety issues reported

Bacteriostatic water, stored upright and secure